Matrix metalloproteinases and small artery remodeling
نویسندگان
چکیده
منابع مشابه
Metalloproteinases, Mechanical Factors and Vascular Remodeling
Chronic increases in arterial blood flow elicit an adaptive response of the arterial wall, leading to vessel enlargement and reduction in wall shear stress to physiological baseline value. Release of nitric oxide from endothelial cells exposed to excessive shear is a fundamental step in the remodeling process, and potentially triggers a cascade of events, including growth factor induction and m...
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Matrix metalloproteinases are an important group of zinc enzymes responsible for degradation of the extracellular matrix components such as collagen and proteoglycans in normal embryogenesis and remodeling and in many disease processes such as arthritis, cancer, periodontitis, and osteoporosis. A matrixin family is defined, comprising at least seven members that range in size from Mr 28,000 to ...
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ژورنال
عنوان ژورنال: Drug Discovery Today: Disease Models
سال: 2011
ISSN: 1740-6757
DOI: 10.1016/j.ddmod.2011.06.002